By George M. Rodgers
This complete quantity discusses the protease ADAMTS13, summarizing the present prestige of simple and medical study. The 9 authoritative chapters start with a historic viewpoint via exploration of the biochemistry and structure-function relationships of ADAMTS13 in addition to its general functionality in hemostasis (cleavage of von Willebrand factor). rising learn topics for ADAMTS13 are lined, together with its capability function in angiogenesis and different elements of phone biology. extra issues comprise laboratory assays for ADAMTS13, inherited ADAMTS13 deficiency, and purchased ADAMTS13 deficiency. A bankruptcy on comparable thrombotic microangiopathic (TMA) problems examines the diversities among TMAs linked to ADAMTS13 deficiency and people now not linked to ADAMTS13 deficiency. a last bankruptcy stories the initial info on rising elements of ADAMTS13, resembling the prestige of recombinant ADAMTS13 items and their strength utility.
Comprehensive in its exploration of the ADAMTS13 protease in disease, ADAMTS13: Biology and affliction is an important source for scientific hematologists, transfusion drugs physicians, and researchers attracted to hemostasis, vascular biology, biochemistry, and metalloproteases.
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ADAMTS13: Biology and Disease by George M. Rodgers